We’ve all heard the saying that, when you’re done taking a tissue sample, you can put it in your bag and go home, but do you really want to take the next step?
Or, even worse, do you even want to?
A recent survey by the American Society of Microbiology (ASM) found that 70 percent of respondents said that they would rather not take a sample from a living human than a dead one.
In an effort to help scientists better understand the impact of the tissue culture on health, scientists are using microorganisms to determine how the human body responds to treatment with drugs.
“This has the potential to help us understand more about disease and how we treat it,” said Dr. Peter Hargreaves, an assistant professor at the University of Rochester’s Department of Pathology and Microbiology and lead author of the study.
The new study, published in the journal Science Translational Medicine, uses the bacterium KEGG2, which is produced by the human microbiome and has a wide range of functions in the body.
The team found that the microbiome plays a role in the production of collagen and elastin, two major proteins found in the skin and bones.
This collagen is a key component of skin that can prevent and heal scars and can also keep the skin healthy and smooth.
“We’re now looking to find out what the microbiome can do for human health,” said study author Dr. Christopher D. Raff, a professor of pathology and microbiology at the New York University School of Medicine.
“There are many areas of human physiology and medicine that are under tremendous investigation.
Understanding how the microbiome influences the body’s health and how that affects disease is critical for treating and preventing diseases.”
The research team looked at the microbiome of the skin in human patients and their healthy relatives, looking at samples from both skin samples and blood samples.
The researchers found that while the skin samples were from healthy people, the blood samples were the best source of information about the bacteria present in the blood.
“What we found was that the microbial communities of skin and blood are very similar,” Raff said.
“You have a few differences but overall they are quite similar.
In the blood, you get different bacteria than in the human skin.
But in the skins, they are very much similar.”
The team then used the microbiome data to create a computer model of the human gut to determine what changes might occur in the microbiome as the human population grows.
For example, if the skin microbiome is becoming more diverse, then we could expect to see a larger number of species in the gut.
“Our model shows that in a given decade, we could see an increase in species diversity in the intestinal tract,” said Raff.
This increase in diversity, in turn, could increase the amount of bacteria in the intestines, which could potentially increase the risk of colon cancer.
“So there are potential effects of these changes that we are trying to understand,” said Hargres.
In addition to looking at the bacteria in human skin, the team also looked at what happens when bacteria in a sample are removed from the skin.
In these experiments, the researchers found changes in the microorganisms in the tissue.
The research showed that the microbes in the samples grew more diverse and, in the process, produced more collagen and other proteins.
“The gut microbiome may have many beneficial properties for the human health, but there are also potential consequences of the growth of these microbes that could be harmful,” said Dabrowski.
Rabinowitz noted that the study shows that the human microbial community has the capacity to be used to learn more about human health.
“One of the key insights that we’ve gotten from this study is that there are a lot of different species that exist in the community and we know that a lot more species have been studied, but we don’t know what they’re doing or how they’re interacting,” said the research team.
“It’s an exciting opportunity to look at what other species might do in the environment, or what other microbes might be going on in the microbiota.”
This research is published in Science Translated by WIRED.
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